Metronidazole CAS 443-48-1

CAS:443-48-1

Fọọmu Molecular:C6H9N3O3

Ìwọ̀n Molikula:171.15

EINECS:207-136-1

Awọn itumọ ọrọ sisọ:TIMTEC-BB SBB001486; 1- (2-Hydroxy-1-ethyl) -2-methyl-5-nitroimidazole; 1- (2-hydroxyethyl) -2-methyl-5-nitroimidazole; 1- (beta-Hydroxyethyl) -2-methyl-5-nitroimidazole; 1- (beta-Oxyethyl) -2-methyl-5-nitroimidazole; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; 1H-Imidazole-1-ethanol,2-methyl-5-nitro-; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2- (2-Methyl-5-nitro-1H-imidazol-1-yl) ethanol; 2-Methyl-1- (2-hydroxyethyl) -5-nitroimidazole

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Kini Metronidazole CAS 443-48-1?

Metronidazole jẹ funfun tabi die-die ofeefee crystalline tabi crystalline lulú; Nibẹ ni kan diẹ wònyí, pẹlu kan kikorò ati die-die salty lenu. Tiotuka die-die ni ethanol, die-die tiotuka ninu omi tabi chloroform, ati lalailopinpin die-die tiotuka ninu ether. Metronidazole jẹ agbo-ara heterocyclic ti o ni nitrogen pẹlu alkalinity ati omi solubility kekere. Gẹgẹbi ilana prodrug, metronidazole ni a ṣe sinu ester potasiomu fosifeti, eyiti o pọ si solubility omi rẹ ati pe o le ṣee lo bi ojutu abẹrẹ.

Sipesifikesonu

Nkan	Sipesifikesonu
Oju omi farabale	301.12°C (iṣiro ti o ni inira)
iwuwo	1.3994 (iṣiro ti o ni inira)
Ojuami yo	159-161°C (tan.)
pKa	pKa 2.62(H2O,t =25±0.2,
Awọn ipo ipamọ	2-8°C

Ohun elo

Metronidazole ni ipa antibacterial to lagbara lori ọpọlọpọ awọn kokoro arun anaerobic ati pe a lo lati ṣe itọju amoebiasis, trichomoniasis, ati awọn akoran kokoro-arun anaerobic. A tun lo lati ṣe itọju trichomoniasis abẹ ati pe o ti lo fun ifun ati amoebiasis extraintestinal lati ọdun 1970. Ipa rẹ ga, majele ti dinku, ati pe o jẹ lilo pupọ. Ni awọn ipa mutagenic ati teratogenic lori awọn adanwo ẹranko.